Exacerbation of pustulosis palmaris et plantaris after topical application of metals accompanied by elevated levels of leukotriene B₄ in pustules - 05/09/11

Doi : 10.1016/S0190-9622(00)90297-4

Koichiro Nakamura, MD, PhD ^a, Sumihisa Imakado, MD, PhD ^b, Mitsuhisa Takizawa, MD ^a, Makoto Adachi, MD ^a, Makoto Sugaya, MD ^a, Motoshi Wakugawa, MD ^a, Akihiko Asahina, MD, PhD ^a, Kunihiko Tamaki, MD, PhD ^a
^a Department of Dermatology, University of Tokyo Tokyo, Japan
^b Department of Dermatology, University of Tsukuba. Tokyo, Japan

Abstract

Background: Pustulosis palmaris et plantaris (PPP) is a chronic inflammatory disease consisting of polymorphonuclear leukocyte infiltration, and is often exacerbated by focal infections such as tonsillitis. In some cases, metal allergy has been reported. Objective: The purpose of this study was to evaluate (1) the significance of metal allergy in the formation of pustules, and (2) the participation of leukotriene (LT) B₄ in the formation of pustules of PPP. Methods: Patch tests with metals were performed on 7 patients with PPP, and both pustular and plasma levels of LTB₄ were measured in these 7 patients before and 48 hours after metal patch tests. Results: Palmoplantar pustules were exacerbated after the metal patch tests in all 7 patients. The mean levels of LTB₄ in plasma and pustules of the volar surface at 48 hours after the metal patch tests were significantly higher than those before the metal patch tests. Conclusion: Metals can be important in the pathogenesis of PPP by contributing to the induction of high LTB₄ concentration in the pustules. (J Am Acad Dermatol 2000;42:1021–5.)

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Plan

Patients

Methods

Measurement of immunoreactive LTB₄ in pustules and plasma of patients with PPP

Statistical analysis

Results

Discussion

	Supported by grants from the Ministry of Education, Science and Culture Ministry of Health and Welfare, and grants from Ono Pharmaceutical Company.
	Reprint requests: K. Nakamura, Department of Dermatology, the University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan 113-0033.
	J Am Acad Dermatol 2000;42:1021–5

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Vol 42 - N° 6

P. 1021-1025 - juin 2000 Retour au numéro

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Exacerbation of pustulosis palmaris et plantaris after topical application of metals accompanied by elevated levels of leukotriene B₄ in pustules - 05/09/11

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