Pemphigus vulgaris induced by D-penicillamine therapy in a patient with systemic sclerosis - 05/09/11
Abstract |
D -Penicillamine–induced pemphigus occurs infrequently, typically in patients with rheumatoid arthritis. We describe a patient with systemic sclerosis who experienced this complication 3 months after starting D -penicillamine therapy. Nikolsky’s sign, histopathologic findings, and direct immunofluorescence all confirmed the diagnosis. Termination of disease progression required intravenous pulse glucocorticoids, azathioprine, and 3 courses of plasmapheresis. The presentation, treatment, and etiology of D -penicillamine-induced pemphigus are reviewed, and the incidence of this complication in scleroderma patients is examined. (J Am Acad Dermatol 2000;42:297-9.)
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Reprint requests: Victoria P. Werth, MD, University of Pennsylvania, 36th and Spruce, Philadelphia, PA 19104. |
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16/54/102644 |
Vol 42 - N° 2P1
P. 297-299 - février 2000 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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