Anti-epiligrin cicatricial pemphigoid with IgG autoantibodies to the β and γ subunits of laminin 5 - 07/09/11
Doi : 10.1016/S0190-9622(99)70453-6
Wataru Fujimoto, MDa, Yôichiro Toi, MDa, Fusako Okazaki, MDa, Zelmira Lazarova, MDb, Kim B. Yancey, MDb, Jirô Arata, MDa
Okayama, Japan, and Bethesda, Maryland
From the Department of Dermatology, Okayama University Medical School,a and the Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda.b
Abstract |
Anti-epiligrin cicatricial pemphigoid is an autoimmune subepithelial blistering disorder of mucous membranes and skin. By immunoblot analyses, sera of most patients with anti-epiligrin cicatricial pemphigoid have been shown to react specifically with the ⍺3 chain of laminin 5. We describe the first patient with anti-epiligrin cicatricial pemphigoid in whom circulating IgG autoantibodies directed against the β3 and γ2-chains of laminin 5 were detected. Treatment with oral prednisolone was beneficial in controlling the disease. (J Am Acad Dermatol 1999;40:637-9.)
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 | Reprint requests: Wataru Fujimoto, MD, Department of Dermatology, Okayama University Medical School, 2-5-1 Shikata, Okayama 700-8558, Japan. |
| 0190-9622/99/$8.00 + 0 16/54/96939 |
© 1999
American Academy of Dermatology, Inc. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 40 - N° 4
P. 637-639 - avril 1999 Retour au numéro
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