Cutaneous angiosarcoma with thrombocytopenia - 07/09/11
Tokyo and Nagasaki, Japan This supplement is made possible through an educational grant from Ortho Dermatologicalto the American Academy of Dermatology. 0190-9622/99/$8.00 + 0 16/4/95645
Abstract |
Thrombocytopenia was observed in 3 patients with cutaneous angiosarcoma of the scalp and face. A sudden decrease in the platelet count occurred in association with rapid enlargement of primary or metastatic lesions. Neither antiplatelet antibody nor platelet-associated IgG was detected. Increased serum levels of β-thromboglobulin and platelet factor 4 indicated that platelets were destroyed and consumed within the vascular bed of the tumor. Prominent PECAM-1 expression on tumor cells may be involved in intratumoral platelet aggregation and consumption. We suggest that the sudden development of profund thrombocytopenia in patients with angiosarcoma may suggest either rapid growth of the primary tumor or herald the development of metastatic disease. (J Am Acad Dermatol 1999;40:872-6.)
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Vol 40 - N° 5S
P. 872-876 - mai 1999 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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