The clinical phenotype of pemphigus is defined by the anti-desmoglein autoantibody profile - 07/09/11
Abstract |
Background: Some patients with pemphigus vulgaris (PV) have mucous membrane erosions with minimal skin involvement (mucosal dominant type), and others show extensive skin blisters and erosions in addition to mucous membrane involvement (mucocutaneous type). Patients with pemphigus foliaceus (PF) show only skin involvement. Objective: The purpose of this study is to determine whether there is a difference in autoantibody profile among mucosal dominant PV, mucocutaneous PV, and PF. Methods: Antibody titer against desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3) were measured with enzyme-linked immunosorbent assay using recombinant Dsg1 and Dsg3. Sera were obtained during clinically active disease from 24 patients with mucosal dominant PV, 20 with mucocutaneous PV, and 23 with PF. Results: All sera samples from patients with mucosal dominant PV sera were negative against Dsg1 but positive against Dsg3. All sera samples from those with mucocutaneous PV were positive against both Dsg1 and Dsg3. All sera samples from patients with PF were positive against Dsg1, but negative against Dsg3. Conclusion: Each subtype has its own anti-Dsg autoantibody profile, indicating that the clinical phenotype of pemphigus is defined by the autoantibody profile. (J Am Acad Dermatol 1999;40:167-70.)
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Supported by Grant-In-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan, and Research Grants for Life Sciences and Medicine, Keio University Medical Science Fund, and Keio Gijuku Academic Development Funds. |
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Reprint requests: Masayuki Amagai, MD, PhD, Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. |
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0190-9622/99/$8.00 + 0 16/1/95202 |
Vol 40 - N° 2
P. 167-170 - février 1999 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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