Hormones and hair patterning in men: A role for insulin-like growth factor 1? - 07/09/11
Abstract |
Background: Androgens are important in hair growth and patterning, whereas growth hormone substitution enhances their effect in growth hormone–deficient men. No previous study has jointly evaluated the function of sex steroids, sex hormone–binding globulin (SHBG), and insulin-like growth factor (IGF-1) in determining hair patterning in men. Objective: We assessed the relationship between circulating hormone measurements and both head and chest hair patterning in a sample of elderly men. Methods: Fifty-one apparently healthy men older than 65 years of age were studied cross-sectionally. Head and chest hair patterning was assessed by a trained interviewer. Morning blood samples from all subjects were used for measurements of testosterone, estradiol, dehydroepiandrosterone sulfate, SHBG, and IGF-1. Results: Results were obtained from logistic regression models, adjusting simultaneously for all the measured hormones and age. Men with higher levels of testosterone were more likely to have vertex baldness (odds ratio [OR] = 2.5, 95% confidence interval [CI: 0.9 to 7.8] per 194 ng/dL increment of testosterone). In addition, for each 59 ng/mL increase in IGF-1, the odds of having vertex baldness doubled (95% CI [1.0 to 4.6]). Those who were found to have higher circulating levels of SHBG were less likely to have dense hair on their chest (OR = 0.4, 95% CI [0.1 to 0.9] per 24 nmol/L increment in SHBG]). Conclusion: Testosterone, SHBG, and IGF-1 may be important in determining hair patterning in men. (J Am Acad Dermatol 1999;40:200-3.)
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Supported in Greece by a grant from the Europe Against Cancer program of the European Union, and in Boston by a grant to Harvard University from George S. Livanos. Lisa B. Signorello is supported by a training award in cancer epidemiology from the US National Institutes of Health, National Cancer Institute (5T32CA09001-21). Christos S. Mantzoros is supported by the Junior Investigator/Hershey Family Awards, Beth Israel Deaconess Medical Center and Harvard Medical School. |
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Reprint requests: Dimitrios Trichopoulos, Department of Epidemiology and Harvard Center for Cancer Prevention, 677 Huntington Ave, Harvard School of Public Health, Boston, MA 02115 |
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Correspondence and reprint requests: Christos S. Mantzoros, Division of Endocrinology, RN 325, Beth Israel Deaconess Medical Center, 99 Brookline Ave, Boston, MA 02215. |
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0190-9622/99/$8.00 + 0 16/1/95509 |
Vol 40 - N° 2
P. 200-203 - février 1999 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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