EMLA cream as a topical anesthetic for the repeated mechanical debridement of venous leg ulcers: A double-blind, placebo-controlled study - 07/09/11
Abstract |
Background: A granulating surface is important for skin grafting and healing of leg ulcers. Mechanical debridement to remove necrotic tissue often must be stopped before completion because of pain. Objective: Our purpose was to assess the effect of EMLA cream on the number of debridements required to obtain a clean ulcer and on pain during debridement and to determine its safety after repeated doses. Methods: In this randomized double-blind, placebo-controlled study, 69 patients with venous leg ulcers received cream before debridement until a clean ulcer was obtained (or a maximum of 15 debridements). Results: EMLA decreased the median number of debridements required for a clean ulcer (EMLA 11.5, placebo >15; P = .019) and decreased pain by 50% (P = .003). Plasma levels of lidocaine, prilocaine, and their main metabolites were low without any apparent accumulation. Conclusion: EMLA produces effective pain relief for the debridement of leg ulcers and shortens the time to a clean ulcer. (J Am Acad Dermatol 1999;40:208-13.)
Le texte complet de cet article est disponible en PDF.Plan
 | Supported by a grant from Laboratoires Astra France. |
| Reprint requests: Catherine Lok, MD, Department of Dermatology of Jean Paul Denoeux, MD, Sud Hospital, Amiens, France. |
 | 0190-9622/99/$8.00 + 0 16/1/94744 |
Vol 40 - N° 2
P. 208-213 - février 1999 Retour au numéro
Article précédent
- NATIONAL REGISTRY FOR ICHTHYOSIS AND RELATED DISORDERS
- Actinically degenerate elastic tissue is the likely antigenic basis of actinic granuloma of the skin and of temporal arteritis
- J.P. O’Brien, W. Regan
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?