Cutaneous CD8+ T cell infiltrates in advanced HIV infection - 07/09/11
Abstract |
Background: Aggressive non-Hodgkin’s lymphomas are common among patients infected with HIV. Although such lymphomas are mostly of the B-cell type, various cases of cutaneous T-cell lymphoma (CTCL) have also been reported. Recent reports suggest that some HIV-related lymphoproliferative conditions may not be clonal processes, but polyclonal lymphoid proliferations. Objective: We reviewed our experience with HIV patients seen at the dermatology clinics for possible CTCL. Methods: A retrospective study was performed to evaluate clinical, laboratory, and histologic findings of HIV-infected patients with atypical T-cell cutaneous infiltrates. Results: We observed 9 patients with advanced HIV infection and a cutaneous eruption characterized by a dense infiltrate of lymphocytes resembling mycosis fungoides histopathologically, but composed of CD8+ cells. Although clonality was not identified in any of the 6 cases tested, 3 patients had similar CD8+ infiltrates involving lymph nodes or bone marrow. Of the 9 patients, 8 died of AIDS wasting syndrome or infections in less than 1 year. Conclusion: Cutaneous and systemic infiltrates with polyclonal CD8 T lymphocytes can be seen in patients with advanced HIV infection and profound CD4 lymphopenia. The clinical presentation may resemble CTCL and is associated with a poor outcome. (J Am Acad Dermatol 1999;41:722-7.)
Le texte complet de cet article est disponible en PDF.Plan
Reprint requests: Joan Guitart, MD, Department of Dermatology, Northwestern University Medical School, Robert H. Lurie Cancer Center, 222 E Superior St, Suite 220, Chicago IL 60611. |
|
0190-9622/99/$8.00 + 0 16/1/99549 |
Vol 41 - N° 5
P. 722-727 - novembre 1999 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?