A randomized comparison of narrow-band TL-01 phototherapy and PUVA photochemotherapy for psoriasis - 07/09/11
Abstract |
Background: Although PUVA treatment of psoriasis is more effective than conventional or broad-band UVB phototherapy, two small studies have suggested that narrow-band or TL-01 phototherapy may have a therapeutic effect equal to PUVA. If confirmed, this would be of considerable importance as TL-01 therapy is likely to be considerably safer in the long term than PUVA. Objective: The purpose of this study was to compare PUVA with narrow-band (TL-01) phototherapy in psoriasis. Methods: We studied 100 patients with plaque-type psoriasis who were randomly allocated to twice-weekly treatment with PUVA or narrow-band UVB. Results: Clearance of psoriasis was achieved in a significantly greater proportion of patients treated with PUVA (84%) than with TL-01 (63%) (P = .018), and with significantly fewer treatments (median number of treatments for clearance with PUVA, 16.7; with TL-01, 25.3; P = .001). Only 12% of those treated with TL-01 were clear of psoriasis 6 months after finishing treatment compared with 35% for PUVA (P = .002). Conclusion: When given twice weekly, PUVA is more effective for psoriasis than narrow-band UVB phototherapy. (J Am Acad Dermatol 1999;41:728-32.)
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Reprint requests: Peter M. Farr, MD, Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK. |
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0190-9622/99/$8.00 + 0 16/1/99605 |
Vol 41 - N° 5
P. 728-732 - novembre 1999 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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