Accelerated growth of dermatofibrosarcoma protuberans during pregnancy - 07/09/11
Abstract |
Dermatofibrosarcoma protuberans (DFSPs) are uncommon skin tumors that have a high incidence of local recurrence even with wide surgical margin, but DFSPs rarely metastasize. Previous reports have suggested that DFSPs may enlarge more rapidly during pregnancy. We report 3 additional cases of DFSPs that showed accelerated growth during pregnancy. Immunohistochemical stains for CD34, S-100 protein, factor XIIIa, and estrogen and progesterone receptors were performed on biopsy specimens. The tumors in all 3 patients, and 4 additional DFSPs from 2 male and 2 female subjects, showed expression of progesterone receptor. As with many other stromal neoplasms, DFSPs appear to express low levels of hormone receptors, which may be one factor that accounts for their accelerated growth during pregnancy. (J Am Acad Dermatol 1999;41:778-83.)
Le texte complet de cet article est disponible en PDF.Plan
 | The opinions or assertions herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army, Department of the Navy, or Department of Defense. |
| Reprint requests: COL Kathleen J. Smith, MC, USA, Departments of Dermatology and Pathology, National Naval Medical Center, 8901 Wisconsin Ave, Bethesda, MD 20889-5600. |
 | 16/54/100562 |
Vol 41 - N° 5
P. 778-783 - novembre 1999 Retour au numéro
Article précédent
- Treatment of rosacea-like demodicidosis with oral ivermectin and topical permethrin cream
- Christa Forstinger, Harald Kittler, Michael Binder
- Patients can accurately identify when they have a dermatologic condition
- Alan B. Fleischer, Steven R. Feldman, Carlin N. Bullard
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?