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Journal of the American Academy of Dermatology
Volume 41, n° 6
pages 1029-1033 (décembre 1999)
Doi : 10.1016/S0190-9622(99)70269-0
Grover’s disease in patients with chronic renal failure receiving hemodialysis: Clinicopathologic review of 4 cases

Josep M. Casanova, MDa, Ramon M. Pujol, MDd, Rosa Taberner, MDd, Ramón Egido, MDb, Elvira Fernández, MDc, Agustí Alomar, MDd
Lleida and Barcelona, Spain 
From the Departments of Dermatology,a Pathology,b and Nephrology,c Hospital Universitari Arnau de Vilanova, Facultat de Medicina de Lleida, and the Department of Dermatology,d Hospital de la Santa Creu i Sant Pau, Universitat Autónoma de Barcelona 


In 4 patients undergoing hemodialysis for chronic renal failure, a transient or persistent, papular and keratotic eruption developed on the trunk and arms. Histologic examination disclosed focal acantholysis with dyskeratosis. The lesions were clinically and histologically indistinguishable from those of Grover’s disease. A possible association with Grover’s disease and chronic renal failure and/or hemodialysis is postulated. Possible implicated pathogenic mechanisms are discussed. We suggest that Grover’s disease should be included in the differential diagnosis of cutaneous eruptions in patients with chronic renal failure. (J Am Acad Dermatol 1999;41:1029-33.)

The full text of this article is available in PDF format.

 Reprint requests: Josep M. Casanova, MD, Department of Dermatology, Hospital Universitari Arnau de Vilanova, Facultat de Medicina de Lleida, Rovira Roure 80, 25199, Lleida, Spain.
 0190-9622/99/$8.00 + 0  16/54/100897

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