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Journal of the American Academy of Dermatology
Volume 39, n° 5
pages 667-690 (novembre 1998)
Doi : 10.1016/S0190-9622(98)70039-8
Cutaneous small-vessel vasculitis

Torello Lotti, MDa, Ilaria Ghersetich, MDa, Claudio Comacchi, MDa, Joseph L. Jorizzo, MDb
Florence, Italy, and Winston-Salem, North Carolina 


Cutaneous small-vessel vasculitis (CSVV) refers to a group of disorders usually characterized by palpable purpura; it is caused by leukocytoclastic vasculitis of postcapillary venules. CSVV can be idiopathic or can be associated with a drug, infection, or underlying systemic disease. Initially, the pathogenesis of CSVV is immune complex related, but in its later stages different pathogenetic mechanisms may intensify the reaction and lymphocytes may predominate in the infiltrate. Cure requires elimination of the cause (ie, drugs, chemicals, infections, food allergens) when possible, as well as therapy with nonsteroidal antiinflammatory agents, corticosteroids, dapsone, potassium iodide, fibrinolytic agents, aminocaproic acid, immunosuppressive agents (ie, cyclophosphamide, azathioprine, methotrexate, cyclosporine) or even monoclonal antibodies, depending on disease severity. (J Am Acad Dermatol 1998;39:667-87.) Learning Objective: At the conclusion of this learning activity, participants should have a firm understanding of the cause, pathogenesis, clinical features, and treatment of CSVV.

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 From the Department of Dermatology, University of Florence,a and the Department of Dermatology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem.b
 Reprint requests: Torello Lotti, MD, 23, via Dante Alighieri, 51016 Montecatini Terme (Pistoia), Italy.
 0190-9622/98/$5.00 + 0   16/2/93190

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