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Journal of the American Academy of Dermatology
Volume 38, n° 5S
pages 806-809 (mai 1998)
Doi : 10.1016/S0190-9622(98)70463-3
Carbamazepine-induced pseudolymphoma with CD-30 positive cells

David L. Nathan, MD, Donald V. Belsito, MD
Division of Dermatology, University of Kansas Medical Center. Kansas City, Kansas 


A 44-year-old woman known to be allergic to phenytoin was treated with carbamazepine for 1 month and developed fever, lymphadenopathy, pneumonitis, hepatitis, and a morbilliform eruption. A skin biopsy specimen showed atypical lymphocytes in the dermis that were CD-3+ , CD-30+ , and L26-. T-cell gene rearrangement studies were negative. A diagnosis of anticonvulsant hypersensitivity syndrome with histologic features of a pseudolymphoma was made and her illness quickly improved after carbamazepine was discontinued. This case was typical of the anticonvulsant hypersensitivity syndrome and demonstrated cross-reactivity among the aromatic anticonvulsants. However, to our knowledge, this represents the first report of a carbamazepine-induced hypersensitivity with histologic features of a cutaneous pseudolymphoma, including CD-30+ cells. (J Am Acad Dermatol 1998;38:806-9.)

The full text of this article is available in PDF format.

 This article is made possible through an educational grant from Ortho Dermatological.
 Reprint request: Donald V. Belsito, MD, University of Kansas Medical Center, Division of Dermatology, 3901 Rainbow Blvd., Kansas City, KS 66160. E-mail: DBELSITO@KUMC.EDU
 0190-9622/98/$5.00 + 0 16/4/88470

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