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Journal of the American Academy of Dermatology
Volume 38, n° 5S
pages 810-814 (mai 1998)
Doi : 10.1016/S0190-9622(98)70464-5
Childhood-onset porphyria cutanea tarda: Successful therapy with low-dose hydroxychloroquine (Plaquenil)
 

Alison J. Bruce, MBChBa, Iftikhar Ahmed, MDa b
Rochester, Minnesota 
From the Departments of Dermatology,a Laboratory Medicine and Pathology,b Mayo Clinic and Mayo Foundation 

Abstract

We describe a 4-year-old girl with a spontaneous blistering disorder that was consistent with porphyria cutanea tarda (PCT). There was no familial history of the disease or any obvious causative factors present. Oral hydroxychloroquine (3 mg/kg) was given twice weekly along with vitamin E (200 U/d) as an antioxidant. Within 6 weeks, marked decreased blistering occurred and by 12 weeks no blistering was evident. Despite clinical improvement and tolerance of hydroxychloroquine, urinary uroporphyrin, asparate aminotransferase, and ferritin levels continued to rise reaching peak levels at 16 weeks of therapy. Near total biochemical remission was observed at 40 weeks and all therapy was discontinued at 60 weeks. (J Am Acad Dermatol 1998;38:810-4.)

The full text of this article is available in PDF format.

 This article is made possible through an educational grant from Ortho Dermatological.
 Reprint requests: I. Ahmed, MD, Department of Dermatology, University of Minnesota, Box 98, 4-240 Phillips-Wangensteen Building, 420 Delaware St. SE, Minneapolis, MN 55455-0392.
 0190-9622/98/$5.00 + 0   16/4/88474



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