Sweet’s syndrome: Is the pathogenesis mediated by helper T cell type 1 cytokines? - 09/09/11
Abstract |
Background: The pathogenesis of Sweet’s syndrome (acute febrile neutrophilic dermatosis; SS) is still not fully understood. An imbalance between helper T cell types 1 and 2 cytokine secretion patterns has been shown to be relevant in many diseases. Objective: We assessed the serum cytokine levels (interleukin [IL]-1⍺, IL-1β, IL-2, interferon gamma [IFN-γ], IL-4) in patients with SS. Methods: Eight patients with SS were analyzed for their clinical features and serum cytokine levels and compared with normal control subjects. Results: In patients serum levels of IL-1⍺, IL-1β, IL-2, and IFN-γ were significantly elevated, whereas the IL-4 level was within the normal range. Conclusion: Our findings suggest that the pathogenesis of SS is probably mediated through helper T cell type 1 cytokines (IL-2, IFN-γ) rather than helper T cell type 2 cytokines (IL-4). (J Am Acad Dermatol 1998;39:940-3.)
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 | Reprint requests: A. S. M. Giasuddin, PhD, Associate Professor of Immunology, Department of Laboratory Medicine, Al-Arab Medical University, PO Box 17383, Benghazi, Libya. |
| 0190-9622/98/$5.00 + 0 16/1/93191 |
Vol 39 - N° 6
P. 940-943 - décembre 1998 Retour au numéro
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