Early-stage HIV infection and hepatitis C virus infection are associated with elevated serum porphyrin levels - 09/09/11
Abstract |
Background: Porphyria cutanea tarda is known to be associated with HIV infection and hepatitis C virus (HCV). Objective: Our purpose was to evaluate whether early infection with HIV, with or without HCV infection, is associated with elevated serum porphyrin levels. Methods: Serum porphyrin levels were measured in samples obtained from 103 patients with early HIV infection. The results were compared with those of 89 late-stage HIV–positive patients and 78 HIV-negative patients. Results: The highest median porphyrin level was in early-stage HIV-positive/HCV-positive samples, followed in decreasing order by those in early-stage HIV-positive/HCV-negative, late-stage HIV-positive/HCV-positive, late-stage HIV-positive/HCV-negative, HIV-negative/HCV-positive, and HIV-negative/HCV-negative groups. Elevated porphyrin levels were independently associated with early-stage HIV infection (P < .0001) and HCV infection (P = .03). Conclusion: This finding suggests abnormal porphyrin metabolism is most noticeable in early-stage HIV infection; it becomes less severe with the progression of HIV disease. (J Am Acad Dermatol 1998;39:956-9.)
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Supported in part by National Institutes of Health grants AI 32424 and AI 27742, and by a Department of Veterans Affairs Merit Review Grant and the Research Center for AIDS and HIV Infection. |
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Reprint requests: Henry W. Lim, MD, Department of Dermatology, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48202-2689. |
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16/1/93797 |
Vol 39 - N° 6
P. 956-959 - décembre 1998 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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