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Journal of the American Academy of Dermatology
Volume 39, n° 3
pages 434-438 (septembre 1998)
Doi : 10.1016/S0190-9622(98)70320-2
accepted : 14 May 1998
Antinuclear antibody seropositivity in patients with cutaneous T-cell lymphoma

S.Ray Peterson, MD, Rakhshandra Talpur, MD, Madeleine Duvic, MD
Section of Dermatology, M. D. Anderson Cancer Center, and the Department of Dermatology, University of Texas Houston Medical School. Houston, Texas 


Background: We attempted to determine the frequency and clinical relevance of antinuclear antibody (ANA) testing and positive ANA test results in patients with cutaneous T-cell lymphoma (CTCL). Methods: A retrospective chart and computer record review was conducted to determine the frequency of ANA testing in CTCL patients and the rate of seropositivity. Patients with a positive ANA were further examined to define possible explanations of the positive test. Results: Of 381 patients with CTCL, 66 (17%) had ANA tests; 8 of these (12.1%) were found to have an ANA titer greater than or equal to 1:40. Of patients with a positive ANA test, one was found to have chronic cutaneous lupus erythematosus histologically and clinically mimicking CTCL. Others were found to have a comorbid connective tissue disorder, some had apparent drug-induced antinuclear antibodies, and some had no identifiable reason for a positive ANA test. Conclusion: ANA seropositivity does not appear to be increased in CTCL patients, and the ANA test remains a useful screening tool for differentiating between CTCL and connective tissue disorders. (J Am Acad Dermatol 1998;39:434-8.)

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 Reprint requests: Madeleine Duvic, MD, Section of Dermatology, M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 28, Houston, TX 77030.
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