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Journal of the American Academy of Dermatology
Volume 39, n° 3
pages 443-446 (septembre 1998)
Doi : 10.1016/S0190-9622(98)70322-6
Kinetics of photosensitivity in bath-PUVA photochemotherapy
 

Claus Gruss, MDa, Stefanie Behrens, MDb, Tilmann Reuther, MDa, Lise Husebo, BAa, Norbert Neumann, MDc, Peter Altmeyer, MDa, Percy Lehmann, MDc, Martina Kerscher, MDb
Bochum, Ulm, and Düsseldorf, Germany 
From the Departments of Dermatology. Ruhr-University Bochum,a University of Ulm,b and Heinrich-Heine University Düsseldorf,c Germany 

Abstract

Background: Bath-PUVA is used to treat a variety of dermatoses. However, the kinetics of 8-methoxypsoralen during treatment are not completely clarified. Objective: The purpose of this study was to investigate the intensity of the phototoxic response and the persistence of phototoxicity after bath-PUVA. Methods: Twelve volunteers were exposed to UVA doses ranging from 0.5 to 40 J/cm2 from 10 to 240 minutes after bath-PUVA treatment. The resulting phototoxic response of the skin was determined. Results: Irradiation 10 minutes after the psoralen bath led to the lowest assessed minimal phototoxic dose (MPD) of 1.42 J/cm2 (mean, SD ± 0.29). Thereafter, the MPD increased significantly and sharply every hour. At 4 hours after the psoralen bath, UVA doses up to 40 J/cm2 failed to induce any phototoxic erythema (MPD). Conclusion: For optimal effects, UVA irradiation has to be administered immediately after the psoralen bath; no restrictive behavior is necessary after bath-PUVA treatment. (J Am Acad Dermatol 1998;39:443-6.)

The full text of this article is available in PDF format.

 Reprint requests: Claus Gruss, MD, Department of Dermatology, University of Regensburg, Franz-Josef-Strauss-Allee 11, D-93042 Regensburg, Germany.
 0190-9622/98/$5.00 + 0  16/1/91720



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