Kinetics of photosensitivity in bath-PUVA photochemotherapy - 09/09/11
Abstract |
Background: Bath-PUVA is used to treat a variety of dermatoses. However, the kinetics of 8-methoxypsoralen during treatment are not completely clarified. Objective: The purpose of this study was to investigate the intensity of the phototoxic response and the persistence of phototoxicity after bath-PUVA. Methods: Twelve volunteers were exposed to UVA doses ranging from 0.5 to 40 J/cm2 from 10 to 240 minutes after bath-PUVA treatment. The resulting phototoxic response of the skin was determined. Results: Irradiation 10 minutes after the psoralen bath led to the lowest assessed minimal phototoxic dose (MPD) of 1.42 J/cm2 (mean, SD ± 0.29). Thereafter, the MPD increased significantly and sharply every hour. At 4 hours after the psoralen bath, UVA doses up to 40 J/cm2 failed to induce any phototoxic erythema (MPD). Conclusion: For optimal effects, UVA irradiation has to be administered immediately after the psoralen bath; no restrictive behavior is necessary after bath-PUVA treatment. (J Am Acad Dermatol 1998;39:443-6.)
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Reprint requests: Claus Gruss, MD, Department of Dermatology, University of Regensburg, Franz-Josef-Strauss-Allee 11, D-93042 Regensburg, Germany. |
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0190-9622/98/$5.00 + 0 16/1/91720 |
Vol 39 - N° 3
P. 443-446 - septembre 1998 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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