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Journal of the American Academy of Dermatology
Volume 38, n° 1
pages 38-44 (janvier 1998)
Doi : 10.1016/S0190-9622(98)70536-5
accepted : 27 August 1997
Lymphocyte subsets and Langerhans cells in sun-protected and sun-exposed skin of immunosuppressed renal allograft recipients

M.Margarida Galvão, MD a, Mírian N. Sotto, MD c, Sonia M. Kihara, MDd, Evandro A. Rivitti, MDe, Emil Sabbaga, MDb
São Paulo, Brazil 


Background: Patients who have received renal allografts experience early aging of the skin, opportunistic infections, and an increased incidence of skin cancer. Objective: We compared the density of lymphocyte subsets and Langerhans cells in normal-appearing skin of renal allograft recipients without skin cancer at 5 to 6 years (group 1) and 14 years after transplant (group 2) with a matched normal control group. Methods: Biopsy specimens of sun-protected and exposed areas from 18 white, kidney allograft recipients (10 in group 1 and 8 in group 2) with normal renal function and from 10 healthy volunteers were semiquantitatively analyzed for dermal lymphocyte subsets and Langerhans cells. Results: There was a statistically significant decrease in all dermal cell elements in the sun-protected skin of both groups of patients who had received grafts. The sun-exposed skin of group 2 also showed a significant decrease of dermal CD4+ and CD8+ lymphocytes, and group 1 had a significant decrease in dermal CD8+ lymphocytes. The dermal CD1a+cell population in the sun-exposed skin from both grafted groups did not differ from the control group. Conclusion: Kidney transplant recipients showed dermal depletion of cells related to immune surveillance against tumors even before skin cancer occurred, and this depletion seemed to become more marked with the duration of immunosuppression. (J Am Acad Dermatol 1998;38:38-44.)

The full text of this article is available in PDF format.

 From the Kidney Transplant Unit,a,b and the Departments of Dermatologyc,d,e and Pathology,c University of São Paulo School of Medicine.
 Reprint requests: Mírian N. Sotto, MD, Faculdade de Medicina USP, Departamento de Patologia, Av. Dr. Arnaldo, 455, 01246—903 São Paulo—SP, Brazil.

© 1998  American Academy of Dermatology, Inc. Published by Elsevier Masson SAS@@#104157@@
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