Mucocutaneous manifestations of the hyper-IgM immunodeficiency syndrome - 09/09/11
Correspondence: Amy S. Paller, MD, Division of Dermatology #107, Children's Memorial Hospital, 2300 Children's Plaza, Chicago, IL 60614-3394.
Abstract |
Background: The recurrent pyogenic infections of patients with hyper-IgM syndrome are controlled by intravenous gamma globulin administration, but patients may suffer from early-onset oral ulcerations and warts. Objective: We have characterized the mucocutaneous manifestations associated with this condition to allow physicians to more readily identify it. Methods: Three male patients with the mucocutaneous manifestations of the hyper-IgM syndrome are described. In one, histopathologic examination of the oral mucosal lesion was performed. Results: Recurrent large, painful oral ulcerations can occur that are not necessarily associated with neutropenia nor do they respond to granulocyte colony-stimulating factor administration. Histopathologic examination of an ulcer showed a heavy infiltrate of mixed inflammatory cells. Warts tend to be widespread and resistant to traditional therapy. Conclusion: Physicians should consider this uncommon condition when examining a male patient with severe oral ulcers or recalcitrant widespread warts. (J Am Acad Dermatol 1998;38:191-6.)
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Reprints not available from the authors. |
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*Dr. Chang is currently with the Department of Dermatology, New York University. |
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0190-9622/98/$5.00 + 0 16/1/87494 |
Vol 38 - N° 2
P. 191-196 - février 1998 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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