Biopsy specimen findings in patients with previous lower extremity cellulitis after saphenous venectomy for coronary artery bypass graft surgery - 11/09/11
Abstract |
Background: No previous study has examined the immune and inflammatory mechanisms involved in the pathogenesis of lower extremity cellulitis after saphenous venectomy for coronary artery bypass graft surgery. Objective: Our purpose was to determine the histopathologic, immunologic, and inflammatory findings in skin biopsy specimens from saphenous venectomy limbs of patients with previous bouts of cellulitis. Methods: Biopsy specimens were obtained from five patients with previous episodes of cellulitis. Specimens of the contralateral lower extremity of each patient were obtained for controlled comparisons. Results: Histopathologic findings did not provide evidence that could account for the tendency for cellulitis to develop. Moreover, the distribution of CD1a, HLA-DR, intercellular adhesion molecule–1, and lymphocyte function–associated antigen type 1 were similar in specimens from the postvenectomy and contralateral legs. No tumor necrosis factor–⍺ expression was found in specimens from the lower extremities. Conclusion: The mechanisms responsible for the production of this disorder do not involve the mediators studied. (J Am Acad Dermatol 1997;37:246-9.)
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Vol 37 - N° 2P1
P. 246-249 - août 1997 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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