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Journal of the American Academy of Dermatology
Volume 36, n° 6
pages 950-955 (juin 1997)
Doi : 10.1016/S0190-9622(97)80279-4
Therapy

Pentostatin (2′-deoxycoformycin) in the treatment of cutaneous T-cell lymphoma
 

Daniela Greiner, MD a, Elise A. Olsen, MD b, , Gina Petroni, PhD b
a Division of Dennatology, Department of Medicine Duke University Medical Center, Durham, North Carolina 
b Division of Biometry, Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina 

**Reprint requests: Elise A. Olsen, MD, Box 3294, Duke University Medical Center, Durham, NC 27710.
Abstract
Background:

The treatment of patients with advanced or therapy-refractory cutaneous T-cell lymphoma (CTCL) remains a challenge. Pentostatin is a potent inhibitor of adenosine deaminase and is selectively toxic to lymphocytes. In a small number of patients with CTCL, it previously has been shown to be effective.

Objective:

Our purpose was to evaluate the efficacy and safety of pentostatin in the treatment of patients with advanced and/or therapy-refractory CTCL.

Methods:

Eighteen patients with stage I to IVb CTCL were treated with 4 to 5 mg/m2 of intravenous pentostatin every 1 to 4 weeks.

Results:

Two patients (11%) had complete responses of 4 months and 6 years, respectively. These patients had stage III and IVa CTCL and had previously received many different external or systemic treatments. Partial remission (50% to 99% clearing) lasting for 1.5 to 6 months occurred in five patients (28%) with stage Ila (n = 3), stage 11b, and stage IVa CTCL. These patients had received a median of three prior external or systemic treatments. No major side effects were observed, and bone marrow suppression was mild.

Conclusion:

Single-agent pentostatin in intravenous doses of 4 to 5 mg/m2 is an effective systemic treatment of CTCL (39% objective response rate) with little toxicity.

The full text of this article is available in PDF format.

* Supported in part by the Mildred Scheel Sfiftung fiir Krebshilfe fellowship (to D. G.).


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