5-Fluorouracil iontophoretic therapy for Bowen's disease - 11/09/11
Abstract |
Background: |
Topical 5-fluorouracil (5-FU) is an accepted therapy for Bowen's disease. Recurrences with this method have been attributed to deep follicular involvement and poor patient compliance because of the prolonged treatment time required.
Objective: |
We sought to determine whether iontophoresis of 5-FU is an effective therapy for Bowen's disease.
Methods: |
Twenty-six patients with biopsy-proven Bowen's disease received eight 5-FU iontophoretic treatments in 4 weeks. Local excision was done 3 months after the last treatment. The specimens were step-sectioned and evaluated for any histologic evidence of bowenoid changes.
Results: |
Only 1 of 26 patients showed histologic evidence of Bowen's disease 3 months after treatment.
Conclusion: |
5-FU iontophoresis appears to be a safe, effective, and well-tolerated therapy for Bowen's disease.
Le texte complet de cet article est disponible en PDF.Vol 36 - N° 6
P. 956-958 - juin 1997 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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