Normal vitamin D levels can be maintained despite rigorous photoprotection: Six years' experience with xeroderma pigmentosum - 11/09/11
Abstract |
Background: Although sun protection is advocated for skin cancer prevention, sunlight is also important in generation of vitamin D in the skin. There is concern that sun protection may result in an abnormally low level of vitamin D. Objective: To assess the risk of vitamin D deficiency in a sunlight-deprived population, we studied eight ambulatory patients with xeroderma pigmentosum (XP) who practiced intensive sun protection during a chemoprevention study of oral isotretinoin. Methods: We surveyed the patients to determine the extent of sun protection and vitamin D intake and measured the serum levels of two vitamin D metabolites (25-hydroxyvitamin D [25-OHD] and 1,25-dihydroxyvitamin D [1,25-(OH)2D]), calcium, and parathyroid hormone during 6 years. Results: The patients all wore protective clothing and sunscreens when outdoors. Estimated mean vitamin D intake was normal. The mean values of serum 25-OHD were low normal, but 1,25-(OH)2D, calcium, ionized calcium and parathyroid hormone levels were normal. Lack of seasonal variation in serum 25-OHD indicated rigorous photoprotection. Conclusion: Despite rigorous sun protection normal vitamin D levels can be maintained in ambulatory patients with XP.
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From the Dermatology Clinical Research Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases,a and the Laboratory of Molecular Carcinogenesis, National Cancer Institute,b National Institutes of Health. |
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Reprint requests: Kenneth H. Kraemer, MD, LMC, NCI, Bldg. 37, Room 3E24, Bethesda, MD 20892. |
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*Dr. Sollitto is now with Voorhees Surgicenter, 2 Van Buren Rd., Voorhees, NJ 08040. |
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**Dr. DiGiovanna is now with the Division of Dermatopharmacology, Department of Dermatology, Brown University School of Medicine, Providence, RI 02903. |
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♢ | 16/1/84630 |
Vol 37 - N° 6
P. 942-947 - décembre 1997 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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