Infantile hypophosphatasia: Treatment options to control hypercalcemia, hypercalciuria, and chronic bone demineralization - 11/09/11
Doi : 10.1016/S0022-3476(97)80029-7
John P. Barcia, MD a, b, c, C. Frederic Strife, MD a, b, c, ⁎, Craig B. Langman, MD a, b, c
a From the Department of Pediatrics, Division of Nephrology, Children's Hospital Medical Center, Northwestern University, Chicago, Illinois, USA
b the University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
c the Department of Pediatrics, Division of Nephrology and Mineral Metabolis, Children's Memorial Hospital, Northwestern University, Chicago, Illinois, USA
1Reprint requests: C. Frederic Strife, MD, Division of Nephrology, Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH 45229-3039.
Abstract |
A 2-month-old child with infantile hypophosphatasia had hypercalcemia (3.49 mmol/L (14 mg/dl)), nephrocalcinosis, and diminished bone mineral content. Hypercalcemia was corrected with calcitonin. Hypercalciuria and bone demineralization abated with chlorothiazide. Hypercalcemia is hypothesized to be related to normal bone resorption in conjunction with impaired bone mineralization. Chlorothiazide may alleviate this impairment.
Le texte complet de cet article est disponible en PDF.Abbreviations : ALP
Plan
| * | Supported in part by U.S. Public Health Service grant No. M01 RR08084 from the General Clinical Research Centers Branch, National Institutes of Health. |
© 1997
Mosby-Year Book, Inc. Tous droits réservés.
Vol 130 - N° 5
P. 825-828 - mai 1997 Retour au numéro
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