Chemotherapy for disseminated actinic keratoses with 5-fluorouracil and isotretinoin - 11/09/11
From the Department of Dermatology, Ludwig-Maximilians-Universitaet, Municha; and the Department of Dermatology, University of Pennsylvania, School of Medicine, Philadelphia.b
Abstract |
Background: Disseminated actinic keratoses are a therapeutic problem.
Objective: Our purpose was to evaluate the efficacy of a combination of topical 5-fluorouracil twice a day and 20 mg of oral isotretinoin daily for disseminated actinic keratoses.
Methods: Twenty-seven patients who had disseminated actinic keratoses (3 women, 24 men) were treated with 5-fluorouracil (5%) twice a day applied to the photodamaged area bearing actinic keratoses along with oral isotretinoin, 20 mg daily. The median treatment time was 21 days.
Results: Actinic keratoses disappeared and signs of photodamaged skin improved in all patients. Side effects were burning and itching as well as painful erosions during the final stage of treatment.
Conclusion: The combination of topical 5-fluorouracil and isotretinoin is highly effective in the treatment of disseminated actinic keratoses on photodamaged skin.
(J Am Acad Dermatol 1997;36:236-8.)
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 | Supported by a grant from the Mildred-Scheel-Stiftung, Bonn, Germany. |
| Reprint requests: Gerd Plewig, MD, Department of Dermatology, Frauenlobstr. 9-11, D-80337 Munich, Germany. |
 | 0190-9622/97/$5.00 + 0 16/1/76200 |
Vol 36 - N° 2
P. 236-238 - février 1997 Retour au numéro
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