Repigmentation in vitiligo vulgaris by autologous minigrafting: Results in nineteen patients - 12/09/11
Reprint requests: W. Westerhof, Netherlands Institute for Pigmentary Disorders (NIP), IWO Building—Academic Medical Center, Meibergdreef 35, 1105 AZ Amsterdam, The Netherlands.Abstract |
Background: Minigrafting is a successful therapy for localized vitiligo but has never been reported for vitiligo vulgaris.
Objective. Our purpose was to evaluate the efficacy of minigrafting in vitiligo vulgaris.
Methods: In 59 patients with stable vitiligo vulgaris, a minigraft test was done by implanting two minigrafts in the lesion to be grafted. Patients were selected for grafting when spread of pigment was observed within 3 months. The rate of repigmentation was evaluated by digital image analysis.
Results: Twenty-three patients (36 lesions), of 24 with a positive minigraft test, were grafted. The results of 19 patients were analyzed, showing 80% to 99% repigmentation in 14 lesions, 50% to 80% repigmentation in 10 lesions, and zero to 50% repigmentation in 12 lesions. Time of observation varied from 3 to 12 months after grafting. Best results were observed after 9 to 12 months. In all patients with a positive Koebner phenomenon depigmentation of the minigrafts developed.
Conclusion: Autologous minigrafting is an effective therapy for stable vitiligo vulgaris in a selected group of patients.
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Vol 33 - N° 6
P. 990-995 - décembre 1995 Retour au numéro
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