Spitz nevi and other Spitzoid lesions : Part I. Background and diagnoses - 12/11/11
Abstract |
Spitz nevi are melanocytic proliferations that are characterized by spindled and/or epithelioid nevomelanocytes. First interpreted as juvenile melanoma, these lesions were later characterized as benign and were observed to affect all age groups. Today, contrasting opinions persist regarding the fundamental benignancy versus malignancy within the spectrum of Spitz tumors. Beyond clinical outcome, this controversy has also been fueled by complex and sometimes convoluted classification schemes based on pathologic characteristics. More recently, immunophenotypic and molecular analyses have begun to clarify the etiologic nature of these tumors. Recent evidence suggests that histopathologic features that suggest more aggressiveness in Spitz tumors relate to mitoses and inflammation.
Le texte complet de cet article est disponible en PDF.Key words : atypical Spitz tumor management, natural history, Spitz nevus
Plan
Supported by a grant from the American Medical Association (Dr Luo), the National Institutes of Health (K24 CA149202-01 to Dr Tsao), the American Cancer Society (RSG MGO-112970 to Dr Tsao) and generous donors to the MGH Millennium Melanoma Fund. |
Vol 65 - N° 6
P. 1073-1084 - décembre 2011 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?