Human herpesvirus 8 is not detectable in lesions of large plaque parapsoriasis, and in early-stage sporadic, familial, and juvenile cases of mycosis fungoides - 16/12/11
Correspondence to: Emmilia Hodak, MD, Department of Dermatology, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel 49100.Abstract |
Background |
Human herpesvirus (HHV) 8, an essential etiologic agent of Kaposi sarcoma, is also associated with several lymphoproliferative disorders. The involvement of HHV 8 in mycosis fungoides (MF) and large plaque parapsoriasis (LPP) is controversial, with contradictory reports from various countries worldwide.
Objective |
We sought to investigate the presence of the HHV 8 genome in skin lesions of LPP and early-stage sporadic, familial, and juvenile MF in patients in Israel.
Methods |
Archival paraffin-embedded and frozen samples from skin biopsies of untreated patients with LPP and early-stage MF performed in 1990 through 2006 were randomly collected from the department of dermatology of a tertiary medical center in central Israel. DNA was extracted, and a TaqMan-based real-time polymerase chain reaction assay specific for the K6 gene region was used to detect the HHV 8 genome.
Results |
A total of 46 biopsies were sampled from 11 patients with LPP and 35 with early-stage MF (17 adults with sporadic MF, 10 children, and 8 patients with familial MF). In all, 44 samples were negative for HHV 8 DNA; two samples from adults with sporadic MF were positive.
Limitations |
The presence of HHV 8 antibodies or virus sequences was not assessed in peripheral blood.
Conclusion |
The results of this study, conducted in a region relatively endemic for HHV 8, support most earlier studies showing a lack of association of HHV 8 infection with LPP and sporadic adult-type MF. To our knowledge, the lack of association of HHV 8 infection with juvenile and familial MF has not been previously reported.
Le texte complet de cet article est disponible en PDF.Key words : familial, human herpesvirus 8, juvenile, lymphoma, mycosis fungoides, parapsoriasis, skin cancer
Abbreviations used : HHV, KS, LPP, MF, PCR, PPP
Plan
| Funding sources: None. |
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| Conflicts of interest: None declared. |
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| Reprints not available from the authors. |
Vol 66 - N° 1
P. 46-50 - janvier 2012 Retour au numéro
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