Oral administration of a hydrophilic extract of Polypodium leucotomos for the prevention of polymorphic light eruption - 16/12/11
, Sonja Radakovic, MD a, Salvador Gonzalez, MD, PhD b, c, Marina Venturini, MD d, Piergiacomo Calzavara-Pinton, MD d
Reprint requests: Adrian Tanew, MD, Department of Dermatology, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.Abstract |
Background |
Polymorphic light eruption (PLE) is the most common idiopathic photodermatosis. Reactive oxygen species have been implicated in the pathogenesis of PLE. Polypodium leucotomos (PL) is a natural extract from tropical fern leaves with potent antioxidant and anti-inflammatory properties.
Objective |
In this study we sought to evaluate whether a concentrated hydrophilic extract of PL might prevent or delay the photoinduction of typical PLE lesions by artificial ultraviolet (UV) radiation.
Methods |
A total of 35 patients with long-standing PLE were included in this open, uncontrolled bicenter study. PLE was induced by photoprovocation with artificial UVB and UVA light, thereafter oral treatment with PL was initiated. Two weeks later a second photoprovocation was performed while the patients were still taking PL.
Results |
Thirty patients developed PLE lesions after repeated irradiation with UVA. Of these, 18 patients also responded to UVB. After PL treatment, 9 (30%) and 5 (28%) patients, respectively, were unresponsive to repeated UVA and UVB exposure. In the remaining patients, the mean number of UVA and UVB irradiations required to elicit PLE increased significantly from 1.95 to 2.62 (P = .005) and from 2.38 to 2.92 (P = .047), respectively.
Limitations |
The study was open and uncontrolled and included a relatively small number of patients.
Conclusion |
Our data indicate that oral PL treatment might be beneficial for the prevention of PLE.
Le texte complet de cet article est disponible en PDF.Key words : antioxidant, photoprovocation, polymorphic light eruption, Polypodium leucotomos, prevention
Abbreviations used : MED, PL, PLE, UV
Plan
| The study was supported by Industrial Farmaceutica Cantabria, Madrid, Spain. |
|
| Disclosure: Dr Gonzalez is a consultant for Industrial Farmaceutica Cantabria. Drs Tanew, Radakovic, Venturini, and Calzavara-Pinton have no conflicts of interest to declare. |
Vol 66 - N° 1
P. 58-62 - janvier 2012 Retour au numéro
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