Cartilage Oligomeric Matrix Protein (COMP) in systemic sclerosis (SSc): Role in disease severity and subclinical rheumatoid arthritis overlap - 11/01/12
Corresponding author. Tel.: +00 20 10 45 67 975.Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 6 |
| Iconographies | 1 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
Objective |
The aim of the present study was to compare the serum level of COMP in both subsets of Systemic sclerosis (SSc) as a marker of arthritis and reveal an associated subclinical RA overlap and a relation to clinical, laboratory and radiological findings in SSc.
Methods |
Forty adult SSc patients were included in the study and grouped into the two subsets diffuse (dSSc) and limited (lSSc) SSc. Their mean age was 40±9years. Thorough history taking and clinical examination were performed to all patients. Skin thickness was scored according to the modified Rodnan skin score method (MRSS). The disease activity was assessed by measuring the Medsger severity score. The joints were extensively examined and the tenderness counted according to the Ritchie articular index (RAI). Relevant laboratory and radiological investigations were carried out. The serum COMP level was determined by ELISA.
Results |
The serum COMP was significantly higher in the SSc patients compared to the control and obviously higher in the dSSc compared to the lSSc patients. The level of COMP was higher in the females and significantly higher in the SSc patients with arthritis (56.5±6.8ug/ml) compared to those without (34±8.3ug/ml) (P 0.000).
Conclusion |
The COMP level may become a nonspecific but useful marker for joint involvement in SSc patients to identify patients at risk of joint damage and developing SSc-RA overlap syndrome even with mild arthritis.
Le texte complet de cet article est disponible en PDF.Keywords : Systemic sclerosis, COMP, RA overlap
Plan
 | The corresponding author certifies that all authors agree to the content, presentation, and decision to submit the manuscript. |
Vol 79 - N° 1
P. 51-56 - janvier 2012 Retour au numéro
Article précédent
- Lack of efficacy of abatacept in axial spondylarthropathies refractory to tumor-necrosis-factor inhibition
- Fernando Kemta Lekpa, Valérie Farrenq, Florence Canouï-Poitrine, Muriel Paul, Xavier Chevalier, Rémy Bruckert, Sylvie Bastuji-Garin, Pascal Claudepierre
- Evaluation of self-report questionnaires for assessing rheumatoid arthritis activity: A cross-sectional study of RAPID3 and RADAI5 and flare detection in 200 patients
- Marie Bossert, Clément Prati, Chrystelle Vidal, Séverine Bongain, Éric Toussirot, Daniel Wendling
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?