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Joint Bone Spine
Volume 79, n° 2
pages 109-112 (mars 2012)
Doi : 10.1016/j.jbspin.2011.11.004
accepted : 9 November 2011
Should anti-TNF-⍺ drug levels and/or anti-drug antibodies be assayed in patients treated for rheumatoid arthritis?

Denis Mulleman a, 1, , b , Emilie Ducourau a, b, 1, Gilles Paintaud a, 1, David Ternant a, c, 1, Hervé Watier a, d, 1, Philippe Goupille a, b, c, 1
a Équipe « Anticorps, récepteurs Fc et réponses cliniques », laboratoire d’Excellence MAbImprove, CNRS UMR 7292, université François-Rabelais de Tours, 3, rue des Tanneurs, 37041 Tours cedex 1, France 
b Service de rhumatologie, CHRU de Tours, 37044 Tours cedex 9, France 
c Laboratoire de pharmacologie-toxicologie et centre pilote de suivi biologique des anticorps thérapeutiques (CePiBAc), CHRU de Tours, 37044 Tours cedex 9, France 
d Laboratoire d’mmunologie et centre pilote de suivi biologique des anticorps thérapeutiques (CePiBAc), CHRU de Tours, 37044 Tours cedex 9, France 

Corresponding author. Tel.: +33 47 47 59 17; fax: +33 47 47 46 39.

Keywords : Biopharmaceuticals, Monoclonal antibodies, Rheumatoid arthritis, Therapeutic drug monitoring, Immunogenicity

© 2012  Published by Elsevier Masson SAS.
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