TNF⍺: Activator or inhibitor of regulatory T cells? - 03/03/12
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Abstract |
TNF⍺ is a cytokine that is central to the pathogenesis of several autoimmune diseases. More specifically, the deleterious effects of TNF⍺ in rheumatoid arthritis (RA) are well established. The proinflammatory influence of TNF⍺ in RA is related both to direct effects mediated by the induction of other proinflammatory cytokines, metalloproteinases, and free radicals; and to modulation of the regulatory T cells (Tregs). Furthermore, the TNF⍺ antagonists used to treat RA can induce the emergence of a distinctive Treg subpopulation. Nevertheless, a recent body of data suggests that TNF⍺ may also exert anti-inflammatory effects, which may be mediated in part via Tregs. TNF⍺ binds to the TNF receptor 2 expressed preferentially at the Treg surface, thereby activating and promoting the development of Tregs. Data from patients with RA and more recent evidence obtained in the absence of disease are consistent with a paradoxical effect of TNF⍺ on Tregs. TNF⍺ may have different effects on naturally occurring Tregs and induced Tregs.
Le texte complet de cet article est disponible en PDF.Keywords : TNF⍺ regulatory T cells, TNF⍺ antagonists, Rheumatoid arthritis
Plan
Vol 79 - N° 2
P. 119-123 - mars 2012 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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