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Joint Bone Spine
Volume 79, n° 2
pages 160-165 (mars 2012)
Doi : 10.1016/j.jbspin.2011.04.009
accepted : 12 April 2011
Serum resistin level is associated with radiographic changes in hand osteoarthritis: Cross-sectional study
 

Jung-Yoon Choe a, 1, Jisuk Bae b, 1, Hyun-Young Jung a, Sung-Hoon Park a, Hyo-Jung Lee a, Seong-Kyu Kim a,
a Department of Internal Medicine, Arthritis and Autoimmunity Research Center, Catholic University of Daegu School of Medicine, 3056-6 Daemyung 4-Dong, Namgu, Daegu 705-718, Republic of Korea 
b Department of Preventive Medicine, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea 

Corresponding author. Tel.: +82 53 650 3038; fax: +82 53 629 8248.
Abstract
Objective

The aim of this study was to determine whether adipokines such as adiponectin and resistin were related to radiographic outcomes in patients with hand osteoarthritis (OA).

Methods

A total of 156 female subjects (46 controls, 60 non-radiographic hand OA, and 50 radiographic hand OA) were enrolled. We measured serum adiponectin and resistin concentrations using an enzyme-linked immunosorbent assay (ELISA). Radiographic hand OA was defined by the presence of a ≥2 Kellgren-Lawrence radiological grade after assessment for 20 joints of both hands. The association between radiographic hand OA and each adipokine was assessed using multivariate logistic regression models controlling for confounding clinical parameters.

Results

Serum resistin levels in radiographic hand OA patients were higher than in non-radiographic hand OA and controls (padj =0.020 and padj =0.019, respectively), whereas there were no significant differences in serum adiponectin levels. The presence of radiographic changes in hand OA was shown to be dependent on serum resistin levels (padj =0.028). Specifically, subchondral erosion in radiographic hand OA was associated with serum resisitin (padj =0.028). However, there were no associations of serum adipokines with joint space narrowing, bony ankylosis, and cortical destruction.

Conclusions

This study suggests that resistin is involved in radiographic changes in hand OA, and that adipokines contribute to pathogenesis in radiographic outcomes in hand OA.

The full text of this article is available in PDF format.

Keywords : Osteoarthritis, Adipokine, Adiponectin, Resistin, Radiography


1  Two authors equally contributed to this manuscript.


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