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Journal of the American Academy of Dermatology
Volume 66, n° 4
pages 515.e1-515.e18 (avril 2012)
Doi : 10.1016/j.jaad.2011.11.960
Continuing Medical Education

Graft-versus-host disease : Part I. Pathogenesis and clinical manifestations of graft-versus-host disease
 

Sharon R. Hymes, MD a, , Amin M. Alousi, MD b, Edward W. Cowen, MD, MHSc c
a Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, Texas 
b Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, Texas 
c Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 

Correspondence to: Sharon R. Hymes, MD, Department of Dermatology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd-434, Houston, TX 77030-4009.
Abstract

Approximately 25,000 allogeneic hematopoietic cell transplants are performed worldwide each year for a variety of malignant and non-malignant conditions. Graft-versus-host disease represents one of the most frequent complications and is a major source of long-term morbidity and mortality. Whereas acute graft-versus-host disease is induced by recognition of host tissues as foreign by immunocompetent donor cells, the pathogenesis of chronic graft-versus-host disease is not as well understood, and continues to be a major treatment challenge. Part I of this two-part series reviews the epidemiologic factors, classification, pathogenesis, and clinical manifestations of acute and chronic graft-versus-host disease. Part II discusses the topical, physical, and systemic treatment options available to patients with graft-versus-host disease.

The full text of this article is available in PDF format.

Key words : fasciitis, fibrosis, graft-versus-host disease, hematopoietic cell transplantation

Abbreviations used : ANA, APC, BAFF, GVHD, GVT, HCT, HPC, HLA, MiHC, NIH, Tregs



 Supported in part by the Intramural Research Program of the National Cancer Institute, Center for Cancer Research.
 Reprints not available from the authors.



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