Article

2 Iconography
Access to the text (HTML) Access to the text (HTML)
PDF Access to the PDF text
Advertising


Access to the full text of this article requires a subscription.
  • If you are a subscriber, please sign in 'My Account' at the top right of the screen.

  • If you want to subscribe to this journal, see our rates



Journal of the American Academy of Dermatology
Volume 66, n° 4
pages 642-649 (avril 2012)
Doi : 10.1016/j.jaad.2010.10.037
Dermatopathology

The histopathological characteristics of male melasma: Comparison with female melasma and lentigo
 

Yong Hyun Jang, MD, Ji Hyun Sim, MD, Hee Young Kang, MD, PhD, You Chan Kim, MD, PhD, Eun-So Lee, MD, PhD
Department of Dermatology, Ajou University School of Medicine, Suwon, Korea 

Correspondence to: Eun-So Lee, MD, PhD, Department of Dermatology, Ajou University School of Medicine, 5 Wonchon-Dong, Yeongtong-Gu, Suwon 443-721, Korea.
Abstract
Background

Knowledge of the histopathology of melasma is a prerequisite for understanding its pathogenesis. However, the histopathological characteristics of male melasma are not well characterized.

Objective

We sought to investigate the histopathological characteristics of melasma in men compared with those of women with melasma and solar lentigo.

Methods

Biopsy specimens were obtained from both the lesional skin and the adjacent nonlesional skin in 8 men with melasma, 10 women with melasma, and 5 men and women each with solar lentigo. The samples were stained using Fontana-Masson and Verhoeff-van Gieson. Immunohistochemistry for melanocytes, the estrogen receptor, progesterone receptor, factor VIIIa–related antigen, stem cell factor, and c-kit was performed.

Results

Increased vascularity was found in the lesion of male melasma. The lesion to nonlesion ratio of the vessel area was increased in male melasma compared with lentigo groups. In the lesion of male melasma, there was a significant increase of stem cell factor and c-kit expression. In addition, the lesion to nonlesion ratio of stem cell factor was increased in male melasma compared with female melasma and lentigo groups. The lesion to nonlesion ratio of c-kit was also increased in male melasma compared with lentigo groups.

Limitations

This study did not include clinical data regarding social habits and was not confirmed by other molecular techniques.

Conclusion

The results suggest that chronic ultraviolet radiation associated with signaling of paracrine cytokines plays an important role in the mechanism associated with hyperpigmentation in male melasma.

The full text of this article is available in PDF format.

Key words : c-kit, estrogen receptor, male melasma, progesterone receptor, stem cell factor

Abbreviations used : ER, LS/NL, PR, SCF, UV



 Funding sources: None.
 Conflicts of interest: None declared.
 Reprints not available from the authors.



© 2011  American Academy of Dermatology, Inc.@@#104156@@
EM-CONSULTE.COM is registrered at the CNIL, déclaration n° 1286925.
As per the Law relating to information storage and personal integrity, you have the right to oppose (art 26 of that law), access (art 34 of that law) and rectify (art 36 of that law) your personal data. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.
Personal information regarding our website's visitors, including their identity, is confidential.
The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Close
Article Outline