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Journal of the American Academy of Dermatology
Volume 66, n° 4
pages 650-654 (avril 2012)
Doi : 10.1016/j.jaad.2011.03.031
Dermatopathology

Primary cutaneous diffuse large B-cell lymphoma, leg type and secondary cutaneous involvement by testicular B-cell lymphoma share identical clinicopathological and immunophenotypical features
 

Cristina Muniesa, MD a, Ramon M. Pujol, MD b, M. Teresa Estrach, MD c, Fernando Gallardo, MD b, M. Pilar García-Muret, MD d, Josefina Climent, MD e, Antonio Salar, MD f, Octavio Servitje, MD g,
a Department of Dermatology, Hospital de Viladecans, Barcelona, Spain 
b Department of Dermatology, Hospital del Mar, Institut Municipal Assistencia Sanitaria (IMAS), Barcelona, Spain 
f Department of Hemathology, Hospital del Mar, Institut Municipal Assistencia Sanitaria (IMAS), Barcelona, Spain 
c Department of Dermatology, Hospital Clínic, Institut Investigacions Biomediques August PI i Sunyer (IDIBAPS), Barcelona, Spain 
d Department of Dermatology, Hospital de Sant Pau, Barcelona, Spain 
g Department of Dermatology, Hospital Universitari de Bellvitge, Institut Investigacio Biomediques Bellvitge (IDIBELL), Hospitalet de Llobregat, Barcelona, Spain 
e Department of Pathology, Hospital Universitari de Bellvitge, Institut Investigacio Biomediques Bellvitge (IDIBELL), Hospitalet de Llobregat, Barcelona, Spain 

Reprint requests: Octavio Servitje, MD, Department of Dermatology, Hospital Universitari de Bellvitge, C/Feixa Llarga s/n, L’ Hospitalet de Llobregat, 08907-Barcelona, Spain.
Abstract
Background

Primary cutaneous diffuse large B-cell lymphoma (PCDLBCL), leg type can eventually disseminate to extracutaneous sites including testes. In addition, patients with testicular lymphoma can develop specific skin involvement.

Objective

We sought to describe similarities between PCDLBCL, leg type and testicular B-cell lymphoma affecting the skin.

Methods

We report two cases with typical clinicopathological and immunophenotypical features of leg type lymphoma occurring simultaneously with a testicular B-cell lymphoma. We also report an additional case of PCDLBCL, leg type with secondary testicular involvement.

Results

All cases presented with typical red tumors exclusively located on the legs. Histologically, all cases showed a diffuse nonepidermotropic infiltrate composed of large blastic cells mainly centroblastic type. Phenotype showed strong positivity for Bcl-2, MUM-1, and FOXP1. Epstein-Barr virus stains and CD30 were negative in the 3 cases. In all cases the testicular infiltration showed the same pathological and phenotypical changes to those observed in the skin.

Limitations

This was a retrospective case series study.

Conclusion

Skin involvement by testicular B-cell lymphomas and PCDLBCL, leg type are indistinguishable on the basis of pathologic and immunophenotypical features, therefore specific investigation and clinic correlation are needed.

The full text of this article is available in PDF format.

Key words : extracutaneous involvement, extracutaneous spread, primary cutaneous diffuse large B-cell lymphoma leg type, secondary cutaneous involvement, testicular involvement, testicular lymphoma

Abbreviations used : CNS, CT, EBV, PCDLBCL



 Funding sources: None.
 Conflicts of interest: None declared.



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