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Journal of the American Academy of Dermatology
Volume 66, n° 4
pages 680-686 (avril 2012)
Doi : 10.1016/j.jaad.2011.10.011
accepted : 9 October 2011
Case & Review

Erosive pustular dermatosis of the scalp: A review with a focus on dapsone therapy

Karen Chen Broussard, MD a, Timothy G. Berger, MD b, Michael Rosenblum, MD b, Jenny E. Murase, MD b, c,
a Department of Dermatology, Vanderbilt Medical Center, Nashville, Tennessee 
b Department of Dermatology, University of California, San Francisco, San Francisco, California 
c Department of Dermatology, Palo Alto Foundation Medical Group, Mountain View, California 

Reprint requests: Jenny E. Murase, MD, Department of Dermatology, Palo Alto Foundation Medical Group, 701 East El Camino Real (31-104), Mountain View, CA 94040.

Erosive pustular dermatosis of the scalp (EPDS) is an inflammatory disorder of unknown origin characterized by pustules, erosions, and crusting in areas of alopecia that tend to be atrophic, actinically damaged, or both. The most common treatments reported include antibiotics and topical anti-inflammatories, which can be ineffective. In the search for effective treatment for EPDS, we share our experience with topical dapsone 5% gel.


We present 4 patients with EPDS, all with classic clinical presentations and histologic findings of EPDS, who had failed a variety of treatments including oral, intralesional, or topical steroids, tacrolimus, and antibiotics. All patients demonstrated rapid improvement or resolution with topical dapsone 5% gel.


Our experience and success with topical dapsone for EPDS is observational and not the result of a randomized controlled trial.


Our observations demonstrate topical dapsone 5% gel to be a novel, safe, and efficacious therapeutic alternative for mild to moderate EPDS.

The full text of this article is available in PDF format.

Key words : dapsone, erosive pustular dermatosis, inflammation, neutrophilic, scalp trauma, topical treatment, ulcer

 Funding sources: None.
 Conflicts of interest: None declared.

© 2011  American Academy of Dermatology, Inc.@@#104156@@
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