The molecular genetics underlying basal cell carcinoma pathogenesis and links to targeted therapeutics - 16/04/12

Doi : 10.1016/j.jaad.2010.06.054

Julie K. Iwasaki, MD ^a, Divya Srivastava, MD ^b, Ronald L. Moy, MD ^c,^d, Henry J. Lin, MD ^e, David J. Kouba, MD, PhD ^a,^f,^⁎
^a Department of Dermatology, Henry Ford Health System, Detroit, Michigan
^b Department of Dermatology, Univerity of Texas Southwestern Medical Center, Dallas, Texas
^c Department of Dermatology, University of California at Los Angeles David Geffen School of Medicine, Los Angeles, California
^d West Los Angeles Veterans Affairs Medical Center, Los Angeles, California
^e Department of Pediatrics and Division of Medical Genetics, Harbor-UCLA Medical Center, Torrance, CA, and the David Geffen School of Medicine, UCLA, Los Angeles, California
^f The Toledo Clinic Dermasurgery and Laser Center, Toledo, Ohio

Reprint requests: David J. Kouba, MD, PhD, Henry Ford Health System, Department of Dermatology, Division of Mohs Micrographic Surgery, 3031 W Grand Blvd, Suite 800, Detroit, MI 48202.

Abstract

Mutations in the sonic hedgehog signaling pathway play a key role in the development of basal cell carcinomas. Specifically, mutations in the PTCH1 (also known as PTCH or PTC1) and SMO genes cause tumor formation through constitutive activation of the pathway. Misregulation of the pathway has also been implicated in the nevoid basal cell carcinoma syndrome and other tumors. Understanding the function of the sonic hedgehog pathway has led to novel strategies for treatment. In this review we highlight the role of the pathway in the pathogenesis of basal cell carcinoma and review potential targeted therapies.

Le texte complet de cet article est disponible en PDF.

Key words : carcinoma, basal cell, sonic hedgehog

Plan

	Funding sources: None.
	Conflicts of interest: None declared.

Export

Vol 66 - N° 5

P. e167-e178 - mai 2012 Retour au numéro

Article précédent

Silver sulfadiazine for the treatment of partial-thickness burns and venous stasis ulcers
Andrew C. Miller, Rashid M. Rashid, Louise Falzon, Elamin M. Elamin, Shahriar Zehtabchi

| Article suivant

Effects of contiguous scars in dermatoscopic evaluation of clinically atypical melanocytic nevi
Hyuk C. Cha, Mandy Harting, Kelly B. Cha, Mathew W. Ludgate, Stephen H. Olsen, Lili Zhao, Christopher D. Lao

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

connectez-vous ou créez un compte

The molecular genetics underlying basal cell carcinoma pathogenesis and links to targeted therapeutics - 16/04/12

Abstract

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL