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Annales de Dermatologie et de Vénéréologie
Volume 139, n° S2
pages 46-52 (avril 2012)
Doi : 10.1016/S0151-9638(12)70110-2
Psoriasis et maladies inflammatoires du tube digestif
Psoriasis and inflammatory bowel diseases

E. Delaporte
Université de Lille 2 et Service de Dermatologie, Hôpital Claude-Huriez, CHRU, Rue Michel Polonovski 59037 Lille cedex, France 


Le psoriasis et les maladies inflammatoires du tube digestif (maladie de Crohn et rectocolite hémorragique) font partie des maladies inflammatoires à médiation immunitaire. Ce groupe comprend environ quatre-vingt affections dont certaines peuvent parfois être associées chez un même malade. Dans le cas du psoriasis, la maladie de Crohn serait un peu plus fréquemment observée, mais la rectocolite hémorragique et la maladie cœliaque sont également concernées. Les liens qui unissent ces affections sont sous-tendus par: i) des données génétiques obtenues par les études de liaisons qui montrent des locus et/ou des gènes prédisposant communs impliqués entre autre dans l’immunité innée; ii) des données immunologiques, ces affections partageant des mécanismes effecteurs de l’inflammation et en particulier la voie d’activation des lymphocytes Th17, ce qui explique l’efficacité conjointe des anticorps anti-TNF et anti-IL-12/23; et iii) des cofacteurs environnementaux parmi lesquels on peut citer le tabac, peut être certaines protéines alimentaires (gliadine…) et les infections bactériennes qui sont probablement déterminantes dans la genèse de ces maladies.

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Psoriasis and inflammatory bowel diseases (Crohn’s disease and ulcerative colitis) are among the immune-mediated inflammatory diseases. This group includes approximately 80 disorders, some of which can at times be associated in a single patient. In psoriasis, Crohn’s disease may be observed slightly more frequently, but ulcerative colitis and celiac disease are also an issue. The underlying relations between these disorders comprise: i) genetic data obtained by genome-wide association studies that show the involvement of shared predisposing loci and/or genes, for example, in innate immunity; ii) immunological data: these disorders share inflammation effector mechanisms, particularly the activation pathway of Th17 lymphocytes, which explains the efficacy of anti-TNF antibodies and anti-IL-12/23; and iii) environmental co-factors such as smoking, possibly certain food proteins (gliadin, etc.), and bacterial infections that are probably decisive elements in the genesis of these diseases.

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Mots clés : Psoriasis, Maladie de Crohn, Rectocolite hémorragique, Maladie cœliaque

Keywords : Psoriasis, Crohn’s disease, Ulcerative colitis, Celiac disease

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