Drug-induced epidermolysis bullosa acquisita with antibodies to type VII collagen - 11/05/12
Abstract |
We describe a 73-year-old patient who had a subepidermal bullous eruption develop after a course of antibiotics, including vancomycin. The patient had deposits of IgA and IgG in the cutaneous basement membrane zone that were located on the dermal side of 1 M NaCl-treated autologous skin. By an enzyme-linked immunosorbent assay, the patient was found to have circulating IgG antibodies directed against type VII collagen, the target antigen of epidermolysis bullosa acquisita. Our observation expands the spectrum of immune-mediated subepidermal bullous skin eruptions precipitated by drugs and lends support to the idea that a subset of these cases represents an unusual variant of drug-triggered epidermolysis bullosa acquisita. (J Am Acad Dermatol 2002;46:S161-4.)
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 | This supplement is made possible through an unrestricted grant from Stiefel Laboratories to the American Academy of Dermatology. |
| Supported by a grant from the Swiss National Foundation for Scientific Research (32-51083.97, to L.B.). |
 | Reprint requests: Luca Borradori, Clinique de Dermatologie, Hôpital Cantonal Universitaire, 24, rue Micheli-du-Crest, CH-1211 Geneva 14, Switzerland. E-mail: Luca.Borradori@hcuge.ch. |
Vol 46 - N° 5S
P. S161-S164 - mai 2002 Retour au numéro
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