Cellular and immunologic mechanisms in atopic dermatitis - 11/05/12
Abstract |
Atopic dermatitis is a chronic inflammatory skin disease that is frequently associated with respiratory allergies. Atopic dermatitis develops as a result of a complex interrelationship of environmental, immunologic, genetic, and pharmacologic factors. Efforts to understand the relative contributions of these factors have led to research seeking to identify the relevant effector cells and mediators involved in the pathogenesis of atopic dermatitis. These factors include the pattern of local cytokine release, the differentiation of helper T cells, multiple roles of IgE, skin-directed cell responses, infectious agents, and superantigens. This article reviews these cellular and immunologic mechanisms underlying atopic dermatitis and discusses how an understanding of their role in the inflammatory process may lead to improved treatments for atopic dermatitis. (J Am Acad Dermatol 2001;44:S1-12.)
Le texte complet de cet article est disponible en PDF.Abbreviations : AD:, cAMP-PDE:, CD:, CLA:, GM-CSF:, IFN:, IgE:, IL:, LPR:, PBMC:, PDE:, PGE2:, TNF:
Plan
Supported by an educational grant from Fujisawa Healthcare, Inc, Deerfield, Illinois. |
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Supported in part by Public Health Services Research Grants HL36577, AR41256, HL37260, and 5 MO1 RR00051. |
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This article is part of a supplement sponsored by Fujisawa Healthcare, Inc. |
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Dr Leung has received grant/research support from Novartis, Fujisawa, and Glaxo and has been on the speakers' bureaus of Glaxo and Schering. Dr Soter has received grant support from Fujisawa Healthcare, Inc. |
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♢ | Reprints are not available. |
♢♢ | J Am Acad Dermatol 2001;44:S1-12. |
Vol 44 - N° 1S
P. S1-S12 - janvier 2001 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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