Pilot study of the effect of postoperative imiquimod 5% cream on the recurrence rate of excised keloids - 11/05/12
Abstract |
New adjunctive treatments are needed to reduce the high recurrence rates (50%) of excised keloids. Interferon alfa injections have been shown to decrease the size of stable keloids. This study examined the effects of postoperative imiquimod 5% cream on the recurrence of 13 keloids excised surgically from 12 patients. Starting on the night of surgery, imiquimod 5% cream was applied for 8 weeks. Patients were examined at weeks 4, 8, 16, and 24 for local erythema, edema, erosions, pigment alteration, and/or recurrence of keloids. Of the 11 keloids evaluated at 24 weeks, none (0%) recurred. Incidences of hyperpigmentation were 63.6%. Two cases of mild irritation and superficial erosion cleared with temporary discontinuation of imiquimod. Both patients completed the 8 weeks of topical therapy and the final 24-week assessment. At 24 weeks, the recurrence rate of excised keloids treated with postoperative imiquimod 5% cream was lower than recurrence rates previously reported in the literature. (J Am Acad Dermatol 2002;47:S209-11.)
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This article is part of a supplement sponsored by 3M Pharmaceuticals. |
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Funding sources: None. |
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Disclosures: Dr Berman is a consultant for 3M Pharmaceuticals and his department has received research funding from 3M Pharmaceuticals. Dr Kaufman has no conflicts of interest to disclose. |
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Reprint requests: Brian Berman, MD, PhD, University of Miami, Department of Dermatology, 1600 NW 10th Ave, Room 2023A, Miami, FL 33136. |
Vol 47 - N° 4S
P. S209-S211 - octobre 2002 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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