Combination azelaic acid therapy for acne vulgaris - 13/06/12
Abstract |
There is no topical antiacne medication that acts against all four of the major pathophysiologic features of acne: hyperkeratinization, sebum production, bacterial proliferation, and inflammation. Topical azelaic acid cream helps both to normalize keratinization and to reduce the proliferation of Propionibacterium acnes, and has proven to be effective against both noninflammatory and inflammatory lesions. The results of a recent study now demonstrate that its efficacy can be enhanced, and patient ratings of overall impression improved, when it is used in combination with other topical medications such as benzoyl peroxide 4% gel, clindamycin 1% gel, tretinoin 0.025% cream, and erythromycin 3%/benzoyl peroxide 5% gel. Furthermore, another study has shown that azelaic acid plus benzoyl peroxide achieves greater efficacy and higher patient ratings of convenience than monotherapy with erythromycin-benzoyl peroxide gel. (J Am Acad Dermatol 2000;43:S47-50.)
Le texte complet de cet article est disponible en PDF.Plan
Supported by Allergan Skin Care. |
|
Reprint requests: Guy Webster, MD, Center for Cutaneous Pharmacology, Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Philadelphia, PA 19107. |
Vol 43 - N° 2P3
P. S47-S50 - août 2000 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?