Association between peripheral vascular endothelial dysfunction and livedoid vasculopathy - 14/06/12
Abstract |
Background |
Livedoid vasculopathy (LV) is a disease characterized by multiple painful and recurrent ulcerations on the feet, accompanied by atrophic scars. Many researchers suggest that a hypercoagulable status is the pathogenetic factor for LV. However, the cause of LV remains elusive.
Objective |
We sought to determine if endothelial dysfunction is present in patients with LV.
Methods |
This prospective study included 16 patients with LV and active ulcers and 16 matched control subjects. We reviewed detailed clinical parameters, including antinuclear antibody, high-sensitivity C-reactive protein, protein C, protein S, homocysteine, anti-SSA, anti-SSB, anticardiolipin antibody, and serum lipid profiles. Flow-mediated vasodilation of the brachial artery was used as an indicator of vascular endothelial function using high-resolution 2-dimensional ultrasonic imaging.
Results |
Blood pressure, blood biochemistry, high-sensitivity C-reactive protein, and homocysteine were not significantly different in patients with LV and control subjects. Nitroglycerin-mediated vasodilation was not significantly different in patients with LV and control subjects. However, flow-mediated vasodilation was much less in patients with LV than in the control group (3.58 ± 2.32% vs 7.51 ± 2.40%, P < .001).
Limitations |
The study was performed at a single site with a limited sample size.
Conclusion |
Peripheral vascular endothelial dysfunction was demonstrated in patients with LV by reduction of brachial flow-mediated vasodilation.
Le texte complet de cet article est disponible en PDF.Key words : endothelial dysfunction, endothelium-dependent flow-mediated vasodilation, livedoid vasculopathy
Abbreviations used : ACA, FMD, hs-CRP, LV, NMD, NO
Plan
Supported by Chang Gung Memorial Hospital grants CMRPG390511 (Drs Yang and Hui), CMRPG370922 (Dr Ho), and CMRPG391241 (Dr Ho). |
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Conflicts of interest: None declared. |
Vol 67 - N° 1
P. 107-112 - juillet 2012 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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