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Pratiques en nutrition
Volume 8, n° 31
pages 31-36 (juillet 2012)
Doi : 10.1016/j.pranut.2012.07.009
Pamplemousse, ami ou ennemi ?
Grapefruit, friend or foe?
 

Daniel Sincholle
Pharmacologue, 485 chemin de Carlencas, 34980 Montferrier-sur-Lez, France 

Résumé

La naringénine, l’un des flavonoïdes du pamplemousse, aurait des propriétés pharmaco-thérapeutiques dans le syndrome métabolique. Il est néanmoins nécessaire, compte tenu de l’interaction connue du jus de pamplemousse avec certains médicaments, de connaître la marge de manœuvre disponible afin d’envisager d’utiliser certains flavonoïdes de ce fruit comme substances thérapeutiques.

The full text of this article is available in PDF format.
Abstract

Naringenin, one of the flavonoids found in grapefruit, is thought to have pharmacotherapeutic properties with regard to metabolic syndrome. It is nevertheless necessary, given the known interaction of grapefruit juice with certain medicines, to be aware of how much leeway there is before envisaging using certain flavonoids from this fruit as therapeutic substances.

The full text of this article is available in PDF format.

Mots-clés : Cytochrome P450, Métabolisme des médicaments, Naringénine, Pamplemousse, Syndrome métabolique

Keywords : Cytochrome P450, Drug metabolism, Grapefruit, Metabolic syndrome


1  L’Agence française de sécurité sanitaire des produits de santé (Afssaps) a publié une mise au point sur l’interaction médicaments et jus de pamplemousse en octobre 2008. http://www.ansm.sante.fr/var/ansm_site/storage/original /application/6ce69646d8057c4b0bba19dea0500a16.pdf.


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