Skin cancer after pancreas transplantation - 14/09/12
Abstract |
Background |
Skin cancer in patients who have undergone pancreas transplantation (PT) has not been extensively characterized.
Objective |
We sought to describe the incidence, tumor burden, and risk factors for skin cancer in PT recipients at Mayo Clinic from 1998 through 2006.
Methods |
A retrospective study was performed by analyzing outcomes among a cohort of pancreas allograft recipients at Mayo Clinic between 1998 and 2006.
Results |
Among 216 allogeneic PT recipients at 2, 5, and 10 years posttransplantation, the cumulative incidence of any skin cancer was 4.7%, 12.7%, and 19.6%; the cumulative incidence of squamous cell carcinoma was 2.8%, 10.3%, and 16.7%; and the cumulative incidence of basal cell carcinoma was 2.4%, 7.8%, and 17.4%, respectively. The cumulative incidence of a second squamous cell carcinoma developing was 56% at 2 years; the cumulative incidence of a second basal cell carcinoma developing was 36% at 2 years. Of the risk factors examined, only age and having a skin cancer before transplantation were predictive of skin cancer development.
Limitations |
This was a retrospective study. Results from a large tertiary center may not be generalizable.
Conclusions |
Nonmelanoma skin cancers commonly occur in recipients of PT, and those patients who have a history of nonmelanoma skin cancer have a very high likelihood of further skin cancer development.
Le texte complet de cet article est disponible en PDF.Key words : basal cell carcinoma, immunosuppression, kidney transplantation, pancreas transplantation, skin cancer, squamous cell carcinoma
Abbreviations used : ATG, BCC, HR, NMSC, PAK, PT, PTA, SCC, SOT, SPK, UV
Plan
Funding sources: None. |
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Conflicts of interest: None declared. |
Vol 67 - N° 4
P. 563-569 - octobre 2012 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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