Solitary mycosis fungoides: A distinct clinicopathologic entity with a good prognosis : A series of 15 cases and literature review - 14/09/12
Reprint requests: Alistair Robson, FRCPath, Dip RCPath, St John’s Institute of Dermatology, St Thomas’ Hospital, Westminster Bridge Road, London, SE1 7EH, UK.Abstract |
Background |
Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma (CTCL), accounting for almost 50% of all primary cutaneous lymphomas. The occurrence of solitary lesions, which are clinically and histopathologically indistinguishable from classic MF has been described.
Objective |
We describe 15 cases of solitary MF and discuss the relationship to classic MF, “reactive” processes and to other, rarer forms of CTCL that may present with solitary lesions.
Methods |
We conducted a retrospective chart review and a PubMed search to identify all reported cases of solitary MF to date, as well as information about other CTCLs presenting as a solitary lesion.
Results |
Fifteen patients were identified. Follow-up data were available on 10 patients with a median follow-up of 10 months (range, 1 to 48 months). Clinical, pathological, immunocytochemical, and molecular-genetic features were analyzed. Five cases were diagnosed as folliculotropic MF (FMF). Of the 10 cases with follow-up, 2 were treated with topical steroids, 2 were completely excised, 5 received radiotherapy, and 1 received tacrolimus. One hundred twenty-eight cases of solitary MF were identified in the literature and reviewed for commonalities to and differences with our cases and other CTCLs.
Limitations |
This study was retrospective; follow-up data were not available in some cases and were only short term in others.
Conclusions |
Solitary MF appears to have a good prognosis. In lesions that are not completely excised, curative radiotherapy can be used. Long-term follow up is advised.
Le texte complet de cet article est disponible en PDF.Key words : cutaneous lymphoma, cutaneous T-cell lymphoma, indolent CD8+ lymphoid proliferation, mycosis fungoides, primary cutaneous CD4+ small/medium pleomorphic T-cell lymphoma, pseudolymphoma, pseudolymphomatous folliculitis, solitary mycosis fungoides, unilesional mycosis fungoides, Woringer-Kolopp disease
Abbreviations used : CTCL, FMF, MF, TCR
Plan
| Funding sources: None. |
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| Conflicts of interest: None declared. |
Vol 67 - N° 4
P. 736-744 - octobre 2012 Retour au numéro
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