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Archives de pédiatrie
Volume 19, n° 10
pages 1086-1088 (octobre 2012)
Doi : 10.1016/j.arcped.2012.07.007
Received : 7 Mars 2012 ;  accepted : 12 July 2012
Cancer papillaire de la thyroïde : second cancer après un rétinoblastome
Papillar thyroid cancer: A rare case of a second primary tumor in retinoblastoma
 

A. de Raphélis Soissan a, , P. Berlier b, L. Claude b, C. Carrie b, D. Frappaz a
a Institut d’hémato-oncologie pédiatrique, 1, place Joseph-Renaut, 69008 Lyon, France 
b Centre Léon-Bérard, 28, rue Laennec, 69373 Lyon cedex, France 

Auteur correspondant.
Résumé

Le rétinoblastome est la tumeur intra-oculaire la plus fréquente de l’enfant. Le pronostic vital est excellent, et l’enjeu thérapeutique actuel est de préserver la fonction visuelle et de limiter les séquelles à moyen et long termes. Le risque de second cancer existe chez tout survivant d’un rétinoblastome, spécialement chez ceux porteurs d’une mutation du gène RB . Il est fortement augmenté par l’irradiation externe. Les formes les plus fréquentes de néoplasie secondaire sont le sarcome des tissus mous et l’ostéosarcome. Nous rapportons 1 cas de cancer de la thyroïde après traitement par radiothérapie d’un rétinoblastome congénital. Le cancer papillaire de la thyroïde est un cancer de bon pronostic, son dépistage systématique doit être proposé chez tout porteur de rétinoblastome irradié.

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Summary

Retinoblastoma is the most common primary cancer of the eye in children. The prognosis for survival is excellent. The current therapy includes an improved survival rate and decreased iatrogenic sequelae. The relative risk of a second tumor in survivors of retinoblastoma is documented, especially in those who carry a germline RB mutation. It is strongly increased in case of radiation therapy. The most common types of second primary tumor are sarcoma of soft tissues and osteosarcoma. We present here a rare case of a retinoblastoma patient who received radiation therapy as a part of his treatment and developed a papillar thyroid cancer as a second malignancy. Papillar thyroid cancer has a good prognosis. Systematic screening for thyroid carcinoma should be undertaken in patients irradiated for congenital retinoblastoma.

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