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Gynécologie Obstétrique & Fertilité
Volume 40, n° 10
pages 614-616 (octobre 2012)
Doi : 10.1016/j.gyobfe.2012.07.003
Received : 13 June 2011 ;  accepted : 28 Mars 2012
Complications de l’association sulfate de magnésium et nicardipine au cours de la prééclampsie : à propos de 2 cas
Complications of association magnesium sulfate with nicardipine during preeclampsia: Report of 2 cases

G. Carles , J. Helou, N. Alassas, F. Dallah, N. Ibrahim
Service de gynécologie-obstétrique, centre hospitalier Franck-Joly, avenue de Gaulle, 97320 Saint-Laurent-du-Maroni, Guyane française 

Auteur correspondant.

Les auteurs rapportent un cas d’insuffisance cardiaque aiguë et un cas de collapsus secondaires à l’administration concomitante de nicardipine et de sulfate de magnésium. Ces deux médicaments ont un effet inotrope négatif et entraînent une baisse des résistances périphériques. L’utilisation du sulfate de magnésium est recommandée en prévention secondaire de l’éclampsie et en prévention primaire de la prééclampsie sévère. Son association avec les inhibiteurs calciques doit être prudente.

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The authors report a heart failure and a collapse following concurrently administration of nicardipine and magnesium sulfate. These two drugs have potential negative inotropic effect and decrease systemic vascular resistance. Magnesium sulfate is the first-line treatment for the prevention of primary and recurrent eclamptic seizures. Combination with calcium channel blockers should be used cautiously.

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Mots clés : Sulfate de magnésium, Nicardipine, Insuffisance cardiaque, Collapsus

Keywords : Magnesium sulfate, Nicardipine, Cardiac insufficiency, Collapsus

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